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Parkinson's Disease in Twins Studied with 18 F-Dopa and Positron Emission tomography Neurol 42:1894-1900, Burn,D.J.,et al, 1992 See this aricle in Pubmed Article Abstract Four of 10 MZ and two of seven DZ asymptomatic co-twins had putamen 18F- dopa uptake reduced more than 2 DSs below the normal mean.Three of these four asymptomatic MZ co-twins had tremor on examination at the time of PET and one has now developed PD 2 years later.Our PET findings give concordances for nigral dysfunction of 45%in the MZ pairs and 29%in the DZ pairs at a 2-SD threshold,and 18%in MZ and 0%in DZ pairs at a 3-SD threshold of significance.These data suggest that the concordance for nigral pathology in PD twins may be higher than previously realized and that the presence of an isolated postural or rest tremor may be a phenotypic expression of PD.

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